Weight Loss

Weight Loss Treatments

at 24 HR Pharmacy

At 24 HR Pharmacy, you can start a clinically guided weight-loss plan from home with three proven options: Mounjaro (tirzepatide), Wegovy (semaglutide), and Orlistat (Xenical). Each treatment works differently, so we match you to the option that fits your health profile, goals, and preferences after a quick online assessment reviewed by our prescribers.

See Treatment Options

Why choose 24 HR Pharmacy

Pharmacist-led: Every request is checked by a UK-registered prescriber against your medical history and current medicines.
Fast, discreet service: Simple online questionnaire, clear next steps, and discreet delivery to your door.
Ongoing support: Guidance on using your treatment safely, plus practical lifestyle tips to help you get results.
Transparent and responsible: We prescribe only when it is safe and appropriate, and we will suggest alternatives if a medicine is not right for you.

Your Treatment Options

Wegovy

Colpermin

Clenil Modulite

Compare Your Options

Choosing the right treatment depends on your health profile, preferences, and goals. Here is a clear, side-by-side view of Mounjaro (tirzepatide), Wegovy (semaglutide), and Orlistat (Xenical) to help you understand how they differ before you complete your assessment.

	Mounjaro (tirzepatide)	Wegovy (semaglutide)	Orlistat (Xenical)
How it works	Incretin-based injection (dual GLP-GLP-1 receptor agonist) that helps reduce appetite and improve fullness.	Incretin-based injection (GLP-1 receptor agonist) that helps you feel fuller and eat less.	Lipase inhibitor capsule that reduces absorption of some dietary fat in the gut.
How you take it	Once-weekly subcutaneous injection using a pre-filled pen.	Once-weekly subcutaneous injection using a pre-filled pen.	Capsule with each main meal that contains fat (up to 3/day).
Typical use	As part of a reduced-calorie diet and increased activity; dose usually titrated gradually.	As part of a reduced-calorie diet and increased activity; dose usually titrated gradually.	Works best with a lower-fat diet to minimise side effects and support weight loss.
Who it may suit	Adults who prefer once-weekly dosing and are comfortable with injections.	Adults who prefer once-weekly dosing and are comfortable with injections.	Adults who prefer tablets and can maintain a lower-fat diet consistently.
Common side effects	Nausea, reflux/indigestion, reduced appetite, constipation or diarrhoea (often settle as dose stabilises).	Nausea, reflux/indigestion, reduced appetite, constipation or diarrhoea (often settle as dose stabilises).	Oily stools, urgent bowel movements, flatulence - more likely with high-fat meals.
Key cautions	Not for use in pregnancy/breastfeeding. Can affect oral contraceptive absorption during dose changes - use additional protection as advised.	Not for use in pregnancy/breastfeeding.	Not for use in pregnancy/breastfeeding; avoid with chronic malabsorption or cholestasis.
Storage	Keep pens refrigerated before first use; follow leaflet for in-use storage.	Keep pens refrigerated before first use; follow leaflet for in-use storage.	Store at room temperature away from moisture.

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When Each Option Makes Sense

Mounjaro (tirzepatide)	Wegovy (semaglutide)	Orlistat (Xenical)
A once-weekly routine with appetite control support. A structured dose-titration plan with prescriber guidance. You are comfortable using an injection pen and compliant with regular check-ins. Not suitable: if you are pregnant/breastfeeding, cannot use injections, or cannot use additional contraception during dose changes when on oral contraceptives.	A once-weekly plan focused on reducing hunger and improving fullness. Clear titration steps and ongoing support on side-effect management. Not suitable: if you are pregnant/breastfeeding or prefer tablets.	A tablet option and are happy to keep dietary fat lower at meals. A non-injectable medicine with straightforward dosing (with each main meal). Not suitable: if your diet is frequently high in fat or you have conditions where orlistat is not suitable (we screen for this).

Mounjaro (tirzepatide)

Wegovy (semaglutide)

Orlistat (Xenical)

A once-weekly routine with appetite control support.
A structured dose-titration plan with prescriber guidance.
You are comfortable using an injection pen and compliant with regular check-ins.

Not suitable: if you are pregnant/breastfeeding, cannot use injections, or cannot use additional contraception during dose changes when on oral contraceptives.

A once-weekly plan focused on reducing hunger and improving fullness.
Clear titration steps and ongoing support on side-effect management.

Not suitable: if you are pregnant/breastfeeding or prefer tablets.

A tablet option and are happy to keep dietary fat lower at meals.
A non-injectable medicine with straightforward dosing (with each main meal).

Not suitable: if your diet is frequently high in fat or you have conditions where orlistat is not suitable (we screen for this).

Who Is Eligible?

We prescribe weight-loss treatment safely and appropriately. Here is how eligibility generally works at 24HR Pharmacy.

Core criteria we check

Age: Adults (18+).
BMI:
- Mounjaro (tirzepatide) & Wegovy (semaglutide): usually BMI 30 or above, or BMI 27+ with a weight-related condition (e.g., high blood pressure, type 2 diabetes, dyslipidaemia, obstructive sleep apnoea). These thresholds reflect the licensed indication.
- Orlistat (Xenical): typically BMI 30 or above, or BMI 28+ with a weight-related condition.
Medical history & medicines: We screen for conditions and drug interactions that would make a treatment unsuitable or require caution (see below).
Pregnancy & breastfeeding: None of these medicines should be used during pregnancy or while breastfeeding.
Lifestyle commitment: All treatments must be used alongside a reduced-calorie diet and increased physical activity.

Note on ethnicity and BMI: UK guidance recognises higher health risk at lower BMI for people from South Asian, Chinese, other Asian, Middle Eastern, Black African or African-Caribbean backgrounds. We take this into account during the assessment, while still prescribing within licensed indications.

How Our Online Service Works?

Simple, safe, and designed around you. Here is what happens from start to finish.

Complete a Quick Online Assessment

Tell us about your health, goals, height/weight (for BMI), medical conditions, and any medicines or supplements you take. This helps us check whether Mounjaro (tirzepatide), Wegovy (semaglutide), or Orlistat (Xenical) is suitable.

What we ask for

Medical history (e.g., diabetes, thyroid, gallbladder, pancreatic issues)
Current medicines (including contraception, blood-pressure or diabetes tablets, anticoagulants)
Allergies and intolerances
Lifestyle factors (diet, activity, alcohol, smoking)
Pregnancy/breastfeeding status and family planning

Review By Our Prescriber

A UK-registered prescriber reviews your answers the same day. If we need anything else (e.g., a recent weight, blood pressure reading, or clarification), we will contact you either via phone or email.

What we check

Eligibility (e.g., BMI and clinical risk factors)
Safety (potential interactions, contraindications, red flags)
Starting dose and titration plan (for injectables) or meal-time guidance (for Orlistat)

If a medicine is not right for you, we will explain why and outline safer alternatives.

Fast, Discreet Dispensing & Delivery

Once approved, we dispense your treatment and send it in discreet packaging.

Cold-chain care for injections: Mounjaro and Wegovy are temperature-sensitive. We ship with appropriate packaging so they arrive in good condition.
Discreet parcels: No external product names on the box.
Convenient options: Home delivery with tracking. You will receive clear instructions inside your parcel.

Start with clear guidance

You will get easy-to-follow instructions tailored to your treatment:

Mounjaro / Wegovy: When and where to inject, dose-by-dose titration, missed-dose instructions, common side effects and what to do if they occur.
Orlistat (Xenical): How to take with main meals, fat-intake guidance, managing side effects, and vitamin supplementation advice if needed.

Ongoing support & refills

We do not just post a parcel - we stay with you.

Check-ins: We encourage regular weight and waist measurements, plus symptom checkers to track tolerance.
Dose adjustments: For injectables, we will guide you through titration and help manage side effects like nausea or reflux.
Re-ordering made simple: Complete a short follow-up questionnaire so we can confirm everything is still safe before each repeat.
Message us anytime: Secure messaging for questions about technique, timing, side effects, or lifestyle tweaks.